Monica is a bioengineer, with expertise in the design and development of microfluidic platforms for cell manipulation. In 2018 she founded MERYLO’, to bring a promising research of using red blood cells as drug delivery systems to the market. From the day of company’s foundation Monica is in charge as a CEO, taking care of the management and networking but still supervising the scientific activities.
Bioengineer, her research activity concerns the hemodialysis and the evaluation of cardiac mechanics alterations in long-term haemodialysis patients. She worked as Professor of Biomedical engineering, at the University of Milan (Italy). She currently is Post-Doc researcher at Politecnico di Milano (Italy) and collaborates with Humanitas University for the use of red cells as molecular carriers. At MERYLO’ she is in charge as CSO and Regulatory and quality referee.
Elena Bianchi is a bioengineer, with a focus on the design, fabrication and characterization of microfluidic devices for biological assays, in particular for shear-stress cellular assays. She is experienced in the use of numerical modeling tools for fluid dynamic, electrical and mechanical design. As a co-founder and CTO of MERYLO’, she is in charge of the scaling up of the microfluidic cartridge to make it become a device suitable for human in-line application, and of the integration of this tool into a biomedical device.
Clara’s background includes a master degree in Medical Biotechnology and Molecular Medicine, five years of professional research experience at IFOM, the FIRC institute of molecular oncology and a PhD in System Medicine (2018). For most of her professional career, she has dealt with cancer research, gaining experience in cell culture, molecular biology techniques, mass spectrometry, atomic force microscopy and abilities to work with animal models. After her PhD she has joined MERYLO’, to design in vitro and in vivo assays to study the release of molecules from red blood cells.
Maria Laura Costantino took the master’s degree in mechanical engineering in 1982 and in 1987 the Ph.D. in Bioengineering. Currently she is full professor in Industrial Bioengineering at Politecnico di Milano. Her research activity has always been dealing with both experimental and theoretical biomechanics focusing mass, momentum and energy transfer in artificial internal organs and in the biological system, cardiovascular fluid dynamics design of biomedical devices interacting with blood and the study of biological-system-to-artificial-organs interaction. Professor Costantino is the responsible of the Laboratory of Life Support Systems, part of the Laboratory of Biological Structure Mechanics (LaBS), at Politecnico di Milano, for research, consulting and teaching activities.
Dott. Carmelo Carlo-Stella graduates in medicine in 1981 at Università degli Studi di Parma and became Haematologist in 1993. He is expert in onco-haematological diseases, with particular regard to lymph-proliferative syndromes (lymphoma, multiple myeloma and leukaemia). It coordinates phase I and II trials based on the use of new drugs for the treatment of patients with relapsed or refractory lymph-proliferative syndromes. Since 2011, he is Head Section of Experimental Therapies in Oncology of the Department of
Ferruccio Miglietta, born in Milan (Italy) on 1955/07/28. Master Degree in Mechanical Engineering; bioengineer. Since 2014 he is a consultant on Medical Devices Regulatory and Quality Management. Since 2017 he is a teacher at courses about Medical Devices (Regulation 2017/745 EU, Risk Management, etc.) and Quality Management System offered by Kiwa-Cermet Italy. From 2005 to 2013: Medical Devices and regulatory Expert, ISO 13485 (Quality Management Systems for medical devices manufacturers) and ISO 9001 (Quality Management Systems) lead Auditor for Det Norske Veritas.
Monica Piergiovanni, Giustina Casagrande, Francesca Taverna, Ilaria Corridori, Marta Frigerio, Elena Bianchi, Flavio Arienti, Arabella Mazzocchi, Gabriele Dubini & Maria Laura Costantino, “Shear-Induced Encapsulation into Red Blood Cells: A New Microfluidic Approach to Drug Delivery”, Annals of Biomedical Engineering, volume 48, pages 236–246 (2020) https://link.springer.com/article/10.1007/s10439-019-02342-w
Costantino Maria Laura, Casagrande Giustina, Piergiovanni Monica, Bianchi Elena. Granted Italian Patent N. 102017000148368 “Eritrociti per la veicolazione di farmaci”
Giustina Casagrande, Flavio Arienti, Arabella Mazzocchi, Francesca Taverna, Fernando Ravagnani & MariaLaura Costantino, “Application of Controlled Shear Stresses on the Erythrocyte Membrane as a New Approach to Promote Molecule Encapsulation”, Artificial Organs, Volume 40, Issue 10, Pages 959-970 (2016) https://onlinelibrary.wiley.com/doi/abs/10.1111/aor.12662